English

A. Advanced Formulation Technologies:

SHJNJ focuses on developing advanced formulation platforms to improve drug solubility/bioavailability

and designing applicable new drug delivery systems. SHJNJ has established and demonstrated strong

in-house expertise and capability in analyzing and resolving many issues related to poor bioavailability

(oral and IV), high absorption variability and delayed onset for many of our client compounds. In addition,

SHJNJ provides not only prototype formulations for in vitro and in vivo testing but also formulation scale

up and manufacturing for clinical batches and commercial productions.

Formulation Platforms

1. Lipoid-based delivery systems

i. self-emulsifying micro emulsions

ii. liposomes

iii. micelles

2. Solid-solution systems (spray dry granules)

3. Nano-particle systems

4. Complexations

5. Controlled drug delivery systems

i. Matrix tablets

ii. OROS tablets

iii. Micro-pellets

6. Transdermal delivery systems

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B. Management of Preclinical and Clinical Drug Development Projects

SHJNJ has developed an efficient system to manage entire formulation development / drug

delivery projects from early drug discovery support, animal PK study, clinical trials, registration

to commercial formulation and manufacture and distrubution, and has attained a great reputation

from its clients in China and oversees.